David J Glass Selected Research

Ligases (Synthetase)

9/2015	The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.
7/2014	MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart.
5/2014	Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy.
2/2011	Voluntary running, skeletal muscle gene expression, and signaling inversely regulated by orchidectomy and testosterone replacement.
5/2010	Signaling pathways perturbing muscle mass.
1/2010	PI3 kinase regulation of skeletal muscle hypertrophy and atrophy.
6/2009	During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.
6/2009	Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.
11/2007	Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.
9/2007	Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.

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David J Glass Research Topics

Disease

25	Atrophy 10/2019 - 02/2003
24	Hypertrophy 10/2019 - 02/2003
13	Muscular Atrophy (Muscle Atrophy) 01/2019 - 02/2003
8	Neoplasms (Cancer) 01/2014 - 08/2003
6	Cardiomegaly (Heart Hypertrophy) 01/2022 - 03/2007
6	Cachexia 11/2017 - 10/2004
4	Sarcopenia 10/2019 - 02/2012
3	Acquired Immunodeficiency Syndrome (AIDS) 01/2021 - 08/2003
2	Heart Failure 01/2019 - 09/2015
2	Neuromuscular Diseases (Neuromuscular Disease) 12/2018 - 12/2014
2	Human Influenza (Influenza) 11/2018 - 12/2014
2	Muscular Diseases (Myopathy) 01/2016 - 09/2007
2	Inflammation (Inflammations) 01/2014 - 01/2013
2	Insulin Resistance 11/2013 - 02/2005
2	Muscular Dystrophies (Muscular Dystrophy) 09/2007 - 11/2005
1	COVID-19 01/2022
1	Cytokine Release Syndrome 01/2022
1	Genomic Instability 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 12/2019
1	Hyperphosphatemia 09/2019
1	Parkinson Disease (Parkinson's Disease) 07/2019
1	Treatment-Resistant Schizophrenia 07/2019
1	Frailty 01/2019
1	X-Linked Bulbo-Spinal Atrophy 12/2018
1	Infections 11/2018
1	Facioscapulohumeral Muscular Dystrophy 01/2018
1	Acne Vulgaris 12/2014
1	Inclusion Body Myositis 12/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2013
1	Cardiovascular Diseases (Cardiovascular Disease) 02/2013

Drug/Important Bio-Agent (IBA)

16	UbiquitinIBA 01/2022 - 02/2003
15	Ligases (Synthetase)IBA 09/2015 - 02/2003
13	Proteins (Proteins, Gene)FDA Link 12/2019 - 02/2003
7	Activins (Activin)IBA 01/2022 - 01/2011
7	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2019 - 08/2003
6	Insulin-Like PeptidesIBA 11/2014 - 08/2003
5	Insulin-Like Growth Factor I (IGF-1)IBA 12/2018 - 01/2005
5	MyostatinIBA 11/2017 - 06/2009
5	GlucocorticoidsIBA 01/2017 - 05/2004
4	CytokinesIBA 01/2022 - 03/2010
4	Transcription Factors (Transcription Factor)IBA 01/2014 - 05/2004
3	LigandsIBA 11/2017 - 02/2014
3	Messenger RNA (mRNA)IBA 11/2014 - 03/2007
3	Insulin (Novolin)FDA Link 11/2013 - 01/2005
3	NF-kappa B (NF-kB)IBA 07/2011 - 10/2004
3	Dexamethasone (Maxidex)FDA LinkGeneric 04/2009 - 01/2005
2	activin AIBA 01/2022 - 02/2014
2	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2022 - 11/2007
2	Mechanistic Target of Rapamycin Complex 1IBA 10/2019 - 11/2018
2	Hormones (Hormone)IBA 09/2019 - 01/2017
2	Pharmaceutical PreparationsIBA 11/2018 - 07/2011
2	Everolimus FDA Link 11/2018 - 12/2014
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 07/2011
2	bimagrumabIBA 12/2014 - 02/2014
2	CalcineurinIBA 07/2014 - 11/2007
2	Myosin Heavy Chains (Myosin Heavy Chain)IBA 02/2014 - 05/2010
2	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA 02/2014 - 11/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2011 - 10/2005
2	Hydrocortisone (Cortisol)FDA LinkGeneric 05/2010 - 11/2007
2	TOR Serine-Threonine KinasesIBA 06/2009 - 01/2005
2	DystrophinIBA 09/2007 - 11/2005
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2005 - 08/2003
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2005 - 08/2003
1	activin BIBA 01/2022
1	A-Form DNA (A-DNA)IBA 01/2021
1	DNA Polymerase IIIIBA 01/2021
1	Zidovudine (Retrovir)FDA LinkGeneric 01/2021
1	NucleosidesIBA 01/2021
1	DNA HelicasesIBA 01/2021
1	HoloenzymesIBA 01/2021
1	Apolipoproteins E (ApoE)IBA 12/2019
1	Neuroprotective AgentsIBA 12/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 10/2019
1	Clozapine (Clozaril)FDA LinkGeneric 07/2019
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 07/2019
1	Indicators and Reagents (Reagents)IBA 01/2019
1	FollistatinIBA 01/2019
1	Androgen Receptors (Androgen Receptor)IBA 12/2018
1	dactolisibIBA 11/2018
1	Antiviral Agents (Antivirals)IBA 11/2018
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2018
1	MetallothioneinIBA 01/2017
1	fibroblast growth factor 21IBA 01/2017
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 01/2017
1	Protein AggregatesIBA 01/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2014
1	Protein Isoforms (Isoforms)IBA 11/2014
1	Anabolic AgentsIBA 11/2014
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2014
1	Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaIBA 11/2014
1	Collagen Type III (Type III Collagen)IBA 11/2014
1	E2F Transcription FactorsIBA 01/2014
1	Nucleic AcidsIBA 01/2014
1	Small Interfering RNA (siRNA)IBA 05/2013
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 05/2013
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 05/2013
1	ClenbuterolIBA 02/2013

Therapy/Procedure

7	Denervation 10/2019 - 05/2004
6	Therapeutics 07/2019 - 02/2011
1	Artificial Respiration (Mechanical Ventilation) 01/2022